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Restoration of p53 activity through exogenous TP53 gene expression has become both a treatment concept for p53-deficient cancers and an important milestone in gene replacement therapy ( Figure 3 )

Currently, no correlation between STG levels in blood or urine and exposure has been demonstrated for humans and more research is needed to fully understand the human in vivo metabolism of STG

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Once available, cagrilintide may be particularly suitable for patients who experience significant GI side effects with GLP-1 medications, those seeking an alternative mechanism for appetite control, or as part of combination therapy for enhanced results